Saturday, September 25
| TIME (ET) | MATCHUP | TV | LINKS |
| 12:00 PM | Bowling Green @ Minnesota |   | Tickets » |
| 12:00 PM | Ohio @ Northwestern | BTN | Tickets » |
| 12:00 PM | #12 Notre Dame vs. #18 Wisconsin* | FOX | Tickets » |
| 12:00 PM | Villanova @ #6 Penn State | BTN | Tickets » |
| 3:30 PM | Illinois @ Purdue | BTN | Preview » Tickets » |
| 3:30 PM | Kent State @ Maryland | BTN | Tickets » |
| 3:30 PM | Rutgers @ #19 Michigan |  | Tickets » |
| 3:30 PM | Colorado State @ #5 Iowa | FOX Sports 1 | Tickets » |
| 7:00 PM | Nebraska @ #20 Michigan State | FOX Sports 1 | Tickets » |
| 7:30 PM | Akron @ #10 Ohio State | BTN | Tickets » |
| 8:00 PM | Indiana @ Western Kentucky | CBS Sports Network | Preview |
